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Medically Important Alterations in Transport Function and Trafficking of ABCG2
Several polymorphisms and mutations in the human ABCG2 multidrug transporter result in reduced plasma membrane expression and/or diminished transport function. Since ABCG2 plays a pivotal role in uric acid clearance, its malfunction may lead to hyperuricemia and gout. On the other hand, ABCG2 residi...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001156/ https://www.ncbi.nlm.nih.gov/pubmed/33801813 http://dx.doi.org/10.3390/ijms22062786 |