Cargando…

Addressing Antiretroviral Drug Resistance with Host-Targeting Drugs—First Steps towards Developing a Host-Targeting HIV-1 Assembly Inhibitor

The concerning increase in HIV-1 resistance argues for prioritizing the development of host-targeting antiviral drugs because such drugs can offer high genetic barriers to the selection of drug-resistant viral variants. Targeting host proteins could also yield drugs that act on viral life cycle even...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lingappa, Jaisri R., Lingappa, Vishwanath R., Reed, Jonathan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001593/ https://www.ncbi.nlm.nih.gov/pubmed/33802145 http://dx.doi.org/10.3390/v13030451

Ejemplares similares

Identification of an Antiretroviral Small Molecule That Appears To Be a Host-Targeting Inhibitor of HIV-1 Assembly
por: Reed, Jonathan C., et al.
Publicado: (2021)

Host ABCE1 is at Plasma Membrane HIV Assembly Sites and Its Dissociation from Gag is Linked to Subsequent Events of Virus Production
por: Dooher, Julia E, et al.
Publicado: (2007)

Mutations of Conserved Residues in the Major Homology Region Arrest Assembling HIV-1 Gag as a Membrane-Targeted Intermediate Containing Genomic RNA and Cellular Proteins
por: Tanaka, Motoko, et al.
Publicado: (2016)

Identifying the assembly intermediate in which Gag first associates with unspliced HIV-1 RNA suggests a novel model for HIV-1 RNA packaging
por: Barajas, Brook C., et al.
Publicado: (2018)

A Multistep, ATP-dependent Pathway for Assembly of Human Immunodeficiency Virus Capsids in a Cell-free System
por: Lingappa, Jaisri R., et al.
Publicado: (1997)

HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly
por: Reed, Jonathan C., et al.
Publicado: (2012)

Transport of Proteins into and across the Endoplasmic Reticulum Membrane
por: PERARA, EVE, et al.
Publicado: (1988)

Combating Intracellular Pathogens with Repurposed Host-Targeted Drugs
por: Schor, Stanford, et al.
Publicado: (2018)

Host-targeting oral antiviral drugs to prevent pandemics
por: Dwek, Raymond A, et al.
Publicado: (2022)

The Landscape of Host Transcriptional Response Programs Commonly Perturbed by Bacterial Pathogens: Towards Host-Oriented Broad-Spectrum Drug Targets
por: Kidane, Yared H., et al.
Publicado: (2013)

Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor
por: Emert-Sedlak, Lori A., et al.
Publicado: (2022)

Targeting the glycans: A paradigm for host‐targeted and COVID‐19 drug design
por: Pourrajab, Fatemeh
Publicado: (2021)

Effect of Pregnancy on Response to Antiretroviral Therapy in HIV-Infected African Women
por: Kourtis, Athena P., et al.
Publicado: (2017)

A Novel Viral Assembly Inhibitor Blocks SARS-CoV-2 Replication in Airway Epithelial Cells
por: Pillai, Satish, et al.
Publicado: (2023)

Using Plasma Viral Load to Guide Antiretroviral Therapy Initiation to Prevent HIV-1 Transmission
por: Murnane, Pamela M., et al.
Publicado: (2012)

Co-Opting Host Receptors for Targeted Delivery of Bioconjugates—From Drugs to Bugs
por: Tummillo, Kristen M., et al.
Publicado: (2021)

Mortality in members of HIV-1 serodiscordant couples in Africa and implications for antiretroviral therapy initiation: Results of analyses from a multicenter randomized trial
por: de Bruyn, Guy, et al.
Publicado: (2012)

Variants in Host Viral Replication Cycle Genes Are Associated With Heterosexual HIV-1 Acquisition in Africans
por: Bigham, Abigail W., et al.
Publicado: (2014)

Systems virology: host-directed approaches to viral pathogenesis and drug targeting
por: Law, G. Lynn, et al.
Publicado: (2013)

The enemy within: Targeting host–parasite interaction for antileishmanial drug discovery
por: Lamotte, Suzanne, et al.
Publicado: (2017)

T Cells Contain an RNase-Insensitive Inhibitor of APOBEC3G Deaminase Activity
por: Thielen, Beth K, et al.
Publicado: (2007)

First steps towards a target laboratory at GANIL
por: Stodel, C, et al.
Publicado: (2004)

Michels syndrome: The first case report from India and review of literature
por: Adio, Adedayo A, et al.
Publicado: (2014)

The host interactome of influenza virus presents new potential targets for antiviral drugs
por: Shaw, Megan L.
Publicado: (2011)

Identifying Host Genetic Risk Factors in the Context of Public Health Surveillance for Invasive Pneumococcal Disease
por: Lingappa, Jairam R., et al.
Publicado: (2011)

Therapeutic targets for HIV-1 infection in the host proteome
por: Liang, Winnie S, et al.
Publicado: (2005)

Carbonic Anhydrase I Is Recognized by an SOD1 Antibody upon Biotinylation of Human Spinal Cord Extracts
por: Liu, Jian, et al.
Publicado: (2010)

Host sequence motifs shared by HIV predict response to antiretroviral therapy
por: Dampier, William, et al.
Publicado: (2009)

Drug-target interactions: only the first step in the commitment to a programmed cell death?
por: Dive, C., et al.
Publicado: (1991)

Future of Antiretroviral Drugs and Evolution of HIV-1 Drug Resistance
por: Charpentier, Charlotte, et al.
Publicado: (2023)

Targeted delivery of mannosylated-PLGA nanoparticles of antiretroviral drug to brain
por: Patel, Bhavin K, et al.
Publicado: (2018)

Spatially Defined Drug Targeting by in Situ Host–Guest Chemistry in a Living Animal
por: Zou, Lei, et al.
Publicado: (2019)

Systematic optimization of host-directed therapeutic targets and preclinical validation of repositioned antiviral drugs
por: Xie, Dafei, et al.
Publicado: (2022)

Meta-analysis of active tuberculosis gene expression ascertains host directed drug targets
por: Ponnusamy, Nirmaladevi, et al.
Publicado: (2022)

Progress towards the 2020 targets for HIV diagnosis and antiretroviral treatment in South Africa
por: Johnson, Leigh F., et al.
Publicado: (2017)

Treatment with Commonly Used Antiretroviral Drugs Induces a Type I/III Interferon Signature in the Gut in the Absence of HIV Infection
por: Hughes, Sean M., et al.
Publicado: (2020)

Previous antiretroviral drug use compromises standard first-line HIV therapy and is mediated through drug-resistance
por: Inzaule, Seth C., et al.
Publicado: (2018)

COVID-19: The cynosure of rise of Parkinson's disease
por: Kukkle, Prashanth Lingappa
Publicado: (2022)

Network-Based Identification and Experimental Validation of Drug Candidates Toward SARS-CoV-2 via Targeting Virus–Host Interactome
por: Fang, Jiansong, et al.
Publicado: (2021)

Integrating Host Genomics with Surveillance for Invasive Bacterial Diseases
por: Crawford, Dana C., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_alt5f52bte8t617mv977h5iubs