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Pan-Cancer Analysis of Human Kinome Gene Expression and Promoter DNA Methylation Identifies Dark Kinase Biomarkers in Multiple Cancers

SIMPLE SUMMARY: Due to their central role in many biological processes, studies on protein kinases are an area of active research. In the last few decades, several inhibitors that target kinases have been approved by U.S. Food and Drug Administration (FDA). However, a large proportion of kinases rem...

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Detalles Bibliográficos
Autores principales: Southekal, Siddesh, Mishra, Nitish Kumar, Guda, Chittibabu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001681/
https://www.ncbi.nlm.nih.gov/pubmed/33801837
http://dx.doi.org/10.3390/cancers13061189