3D Pharmacophore-Based Discovery of Novel K(V)10.1 Inhibitors with Antiproliferative Activity

SIMPLE SUMMARY: A novel structural class of inhibitors of the voltage-gated potassium channel K(V)10.1 was discovered by a ligand-based drug design method using a 3D pharmacophore model. The virtual screening hit compound ZVS-08 inhibited the channel in a voltage-dependent manner consistent with the...

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Detalles Bibliográficos
Autores principales: Toplak, Žan, Hendrickx, Louise Antonia, Gubič, Špela, Možina, Štefan, Žegura, Bojana, Štern, Alja, Novak, Matjaž, Shi, Xiaoyi, Peigneur, Steve, Tytgat, Jan, Tomašič, Tihomir, Pardo, Luis A., Mašič, Lucija Peterlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002023/
https://www.ncbi.nlm.nih.gov/pubmed/33808994
http://dx.doi.org/10.3390/cancers13061244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002023/
https://www.ncbi.nlm.nih.gov/pubmed/33808994
http://dx.doi.org/10.3390/cancers13061244

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