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Peppers: A “Hot” Natural Source for Antitumor Compounds

Piper, Capsicum, and Pimenta are the main genera of peppers consumed worldwide. The traditional use of peppers by either ancient civilizations or modern societies has raised interest in their biological applications, including cytotoxic and antiproliferative effects. Cellular responses upon treatmen...

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Autores principales: Cunha, Micael Rodrigues, Tavares, Maurício Temotheo, Fernandes, Thais Batista, Parise-Filho, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002096/
https://www.ncbi.nlm.nih.gov/pubmed/33802144
http://dx.doi.org/10.3390/molecules26061521
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author Cunha, Micael Rodrigues
Tavares, Maurício Temotheo
Fernandes, Thais Batista
Parise-Filho, Roberto
author_facet Cunha, Micael Rodrigues
Tavares, Maurício Temotheo
Fernandes, Thais Batista
Parise-Filho, Roberto
author_sort Cunha, Micael Rodrigues
collection PubMed
description Piper, Capsicum, and Pimenta are the main genera of peppers consumed worldwide. The traditional use of peppers by either ancient civilizations or modern societies has raised interest in their biological applications, including cytotoxic and antiproliferative effects. Cellular responses upon treatment with isolated pepper-derived compounds involve mechanisms of cell death, especially through proapoptotic stimuli in tumorigenic cells. In this review, we highlight naturally occurring secondary metabolites of peppers with cytotoxic effects on cancer cell lines. Available mechanisms of cell death, as well as the development of analogues, are also discussed.
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spelling pubmed-80020962021-03-28 Peppers: A “Hot” Natural Source for Antitumor Compounds Cunha, Micael Rodrigues Tavares, Maurício Temotheo Fernandes, Thais Batista Parise-Filho, Roberto Molecules Review Piper, Capsicum, and Pimenta are the main genera of peppers consumed worldwide. The traditional use of peppers by either ancient civilizations or modern societies has raised interest in their biological applications, including cytotoxic and antiproliferative effects. Cellular responses upon treatment with isolated pepper-derived compounds involve mechanisms of cell death, especially through proapoptotic stimuli in tumorigenic cells. In this review, we highlight naturally occurring secondary metabolites of peppers with cytotoxic effects on cancer cell lines. Available mechanisms of cell death, as well as the development of analogues, are also discussed. MDPI 2021-03-10 /pmc/articles/PMC8002096/ /pubmed/33802144 http://dx.doi.org/10.3390/molecules26061521 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cunha, Micael Rodrigues
Tavares, Maurício Temotheo
Fernandes, Thais Batista
Parise-Filho, Roberto
Peppers: A “Hot” Natural Source for Antitumor Compounds
title Peppers: A “Hot” Natural Source for Antitumor Compounds
title_full Peppers: A “Hot” Natural Source for Antitumor Compounds
title_fullStr Peppers: A “Hot” Natural Source for Antitumor Compounds
title_full_unstemmed Peppers: A “Hot” Natural Source for Antitumor Compounds
title_short Peppers: A “Hot” Natural Source for Antitumor Compounds
title_sort peppers: a “hot” natural source for antitumor compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002096/
https://www.ncbi.nlm.nih.gov/pubmed/33802144
http://dx.doi.org/10.3390/molecules26061521
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