Actin-Resistant DNase1L2 as a Potential Therapeutics for CF Lung Disease

In cystic fibrosis (CF), the accumulation of viscous lung secretions rich in DNA and actin is a major cause of chronic inflammation and recurrent infections leading to airway obstruction. Mucolytic therapy based on recombinant human DNase1 reduces CF mucus viscosity and promotes airway clearance. Ho...

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Detalles Bibliográficos
Autores principales: Delfino, Danila, Mori, Giulia, Rivetti, Claudio, Grigoletto, Antonella, Bizzotto, Gloria, Cavozzi, Cristian, Malatesta, Marco, Cavazzini, Davide, Pasut, Gianfranco, Percudani, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002113/
https://www.ncbi.nlm.nih.gov/pubmed/33802146
http://dx.doi.org/10.3390/biom11030410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002113/
https://www.ncbi.nlm.nih.gov/pubmed/33802146
http://dx.doi.org/10.3390/biom11030410

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