Cargando…

Actin-Resistant DNase1L2 as a Potential Therapeutics for CF Lung Disease

In cystic fibrosis (CF), the accumulation of viscous lung secretions rich in DNA and actin is a major cause of chronic inflammation and recurrent infections leading to airway obstruction. Mucolytic therapy based on recombinant human DNase1 reduces CF mucus viscosity and promotes airway clearance. Ho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Delfino, Danila, Mori, Giulia, Rivetti, Claudio, Grigoletto, Antonella, Bizzotto, Gloria, Cavozzi, Cristian, Malatesta, Marco, Cavazzini, Davide, Pasut, Gianfranco, Percudani, Riccardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002113/ https://www.ncbi.nlm.nih.gov/pubmed/33802146 http://dx.doi.org/10.3390/biom11030410

Ejemplares similares

Origin and significance of the human DNase repertoire
por: Mori, Giulia, et al.
Publicado: (2022)

Identification of hidden associations among eukaryotic genes through statistical analysis of coevolutionary transitions
por: Dembech, Elena, et al.
Publicado: (2023)

Functional characterization and transcriptional repression by Lacticaseibacillus paracasei DinJ-YafQ
por: Bonini, Aleksandra Anna, et al.
Publicado: (2022)

cfDNA and DNases: New Biomarkers of Sepsis in Preterm Neonates—A Pilot Study
por: Lenz, Moritz, et al.
Publicado: (2022)

Improving the Therapeutic Potential of G-CSF through Compact Circular PEGylation Based on Orthogonal Conjugations
por: Grigoletto, Antonella, et al.
Publicado: (2023)

Birth of a pathway for sulfur metabolism in early amniote evolution
por: Malatesta, Marco, et al.
Publicado: (2020)

Folic Acid-Targeted Paclitaxel-Polymer Conjugates Exert Selective Cytotoxicity and Modulate Invasiveness of Colon Cancer Cells
por: Grigoletto, Antonella, et al.
Publicado: (2021)

Efficacy of PEGylated ciliary neurotrophic factor superagonist variant in diet-induced obesity mice
por: Battista, Maria Rosaria, et al.
Publicado: (2022)

Role of actin in the responses of adrenal cells to ACTH and cyclic AMP: inhibition by DNase I
Publicado: (1984)

Dysregulation of the actin scavenging system and inhibition of DNase activity following severe thermal injury
por: Dinsdale, R. J., et al.
Publicado: (2019)

Cysteine Enrichment Mediates Co-Option of Uricase in Reptilian Skin and Transition to Uricotelism
por: Mori, Giulia, et al.
Publicado: (2023)

Toward the identification of a type I toxin-antitoxin system in the plasmid DNA of dairy Lactobacillus rhamnosus
por: Folli, Claudia, et al.
Publicado: (2017)

Evolution of the Selenoproteome in Helicobacter pylori and Epsilonproteobacteria
por: Cravedi, Pietro, et al.
Publicado: (2015)

Grand Challenges in Nano-Based Drug Delivery
por: Pasut, Gianfranco
Publicado: (2019)

Death DNase tied down
por: LeBrasseur, Nicole
Publicado: (2004)

The Biology of Cell-free DNA Fragmentation and the Roles of DNASE1, DNASE1L3, and DFFB
por: Han, Diana S.C., et al.
Publicado: (2020)

A cookbook for DNase Hi-C
por: Gridina, Maria, et al.
Publicado: (2021)

Ureidoglycolate hydrolase, amidohydrolase, lyase: how errors in biological databases are incorporated in scientific papers and vice versa
por: Percudani, Riccardo, et al.
Publicado: (2013)

Current bioinformatic approaches to identify DNase I hypersensitive sites and genomic footprints from DNase-seq data
por: Madrigal, Pedro, et al.
Publicado: (2012)

Improved DNase-seq protocol facilitates high resolution mapping of DNase I hypersensitive sites in roots in Arabidopsis thaliana
por: Cumbie, Jason S., et al.
Publicado: (2015)

Renal Dnase1 expression is regulated by FGF23 but loss of Dnase1 does not alter renal phosphate handling
por: Egli-Spichtig, Daniela, et al.
Publicado: (2021)

Epistatic effects of Siglec-G and DNase1 or DNase1l3 deficiencies in the development of systemic lupus erythematosus
por: Korn, Marina A., et al.
Publicado: (2023)

Eradication of Human Ovarian Cancer Cells by Transgenic Expression of Recombinant DNASE1, DNASE1L3, DNASE2, and DFFB Controlled by EGFR Promoter: Novel Strategy for Targeted Therapy of Cancer
por: Malecki, Marek, et al.
Publicado: (2013)

STREPTOCOCCAL NUCLEASES : II. CHARACTERIZATION OF DNASE D
por: Wannamaker, Lewis W., et al.
Publicado: (1967)

Anti-DNA antibodies bind to DNase I
Publicado: (1995)

DNase-I-dependent dissociation of erythrocyte cytoskeletons
Publicado: (1979)

Tumoricidal Activity of RNase A and DNase I
por: Patutina, O.A., et al.
Publicado: (2010)

Biogenesis and Proteolytic Processing of Lysosomal DNase II
por: Ohkouchi, Susumu, et al.
Publicado: (2013)

Mapping nucleosome positions using DNase-seq
por: Zhong, Jianling, et al.
Publicado: (2016)

A closer look into DNase I hypersensitivity
por: He, Housheng Hansen, et al.
Publicado: (2013)

Neutrophil Extracellular Traps-DNase Balance and Autoimmunity
por: Angeletti, Andrea, et al.
Publicado: (2021)

Theoretical insight into OH- and Cl-initiated oxidation of CF(3)OCH(CF(3))(2) and CF(3)OCF(2)CF(2)H & fate of CF(3)OC(X•)(CF(3))(2) and CF(3)OCF(2)CF(2)X• radicals (X=O, O(2))
por: Bai, Feng-Yang, et al.
Publicado: (2017)

A Microbial Metagenome (Leucobacter sp.) in Caenorhabditis Whole Genome Sequences
por: Percudani, Riccardo
Publicado: (2013)

Inactivation of DNase1L2 and DNase2 in keratinocytes suppresses DNA degradation during epidermal cornification and results in constitutive parakeratosis
por: Fischer, Heinz, et al.
Publicado: (2017)

Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis
por: Schäfer, Jürgen, et al.
Publicado: (2018)

DNase and atelectasis in non-cystic fibrosis pediatric patients
por: Hendriks, Tom, et al.
Publicado: (2005)

Multicomponent synthesis of artificial nucleases and their RNase and DNase activity
por: Gulevich, Anton V, et al.
Publicado: (2011)

Dispersal of Biofilms by Secreted, Matrix Degrading, Bacterial DNase
por: Nijland, Reindert, et al.
Publicado: (2010)

Comparative evaluation of DNase-seq footprint identification strategies
por: Barozzi, Iros, et al.
Publicado: (2014)

Purification of an Inducible DNase from a Thermophilic Fungus
por: Landry, Kyle S., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_6dq7p1ojbtissbq4t7e5kt84p5