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Anti-Cancer Effects of Carnosine—A Dipeptide Molecule

Background: Carnosine is a dipeptide molecule (β-alanyl-l-histidine) with anti-inflammatory, antioxidant, anti-glycation, and chelating properties. It is used in exercise physiology as a food supplement to increase performance; however, in vitro evidence suggests that carnosine may exhibit anti-canc...

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Autores principales: Prakash, Monica D., Fraser, Sarah, Boer, Jennifer C., Plebanski, Magdalena, de Courten, Barbora, Apostolopoulos, Vasso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002160/
https://www.ncbi.nlm.nih.gov/pubmed/33809496
http://dx.doi.org/10.3390/molecules26061644
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author Prakash, Monica D.
Fraser, Sarah
Boer, Jennifer C.
Plebanski, Magdalena
de Courten, Barbora
Apostolopoulos, Vasso
author_facet Prakash, Monica D.
Fraser, Sarah
Boer, Jennifer C.
Plebanski, Magdalena
de Courten, Barbora
Apostolopoulos, Vasso
author_sort Prakash, Monica D.
collection PubMed
description Background: Carnosine is a dipeptide molecule (β-alanyl-l-histidine) with anti-inflammatory, antioxidant, anti-glycation, and chelating properties. It is used in exercise physiology as a food supplement to increase performance; however, in vitro evidence suggests that carnosine may exhibit anti-cancer properties. Methods: In this study, we investigated the effect of carnosine on breast, ovarian, colon, and leukemic cancer cell proliferation. We further examined U937 promonocytic, human myeloid leukemia cell phenotype, gene expression, and cytokine secretion to determine if these are linked to carnosine’s anti-proliferative properties. Results: Carnosine (1) inhibits breast, ovarian, colon, and leukemic cancer cell proliferation; (2) upregulates expression of pro-inflammatory molecules; (3) modulates cytokine secretion; and (4) alters U937 differentiation and phenotype. Conclusion: These effects may have implications for a role for carnosine in anti-cancer therapy.
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spelling pubmed-80021602021-03-28 Anti-Cancer Effects of Carnosine—A Dipeptide Molecule Prakash, Monica D. Fraser, Sarah Boer, Jennifer C. Plebanski, Magdalena de Courten, Barbora Apostolopoulos, Vasso Molecules Article Background: Carnosine is a dipeptide molecule (β-alanyl-l-histidine) with anti-inflammatory, antioxidant, anti-glycation, and chelating properties. It is used in exercise physiology as a food supplement to increase performance; however, in vitro evidence suggests that carnosine may exhibit anti-cancer properties. Methods: In this study, we investigated the effect of carnosine on breast, ovarian, colon, and leukemic cancer cell proliferation. We further examined U937 promonocytic, human myeloid leukemia cell phenotype, gene expression, and cytokine secretion to determine if these are linked to carnosine’s anti-proliferative properties. Results: Carnosine (1) inhibits breast, ovarian, colon, and leukemic cancer cell proliferation; (2) upregulates expression of pro-inflammatory molecules; (3) modulates cytokine secretion; and (4) alters U937 differentiation and phenotype. Conclusion: These effects may have implications for a role for carnosine in anti-cancer therapy. MDPI 2021-03-16 /pmc/articles/PMC8002160/ /pubmed/33809496 http://dx.doi.org/10.3390/molecules26061644 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Prakash, Monica D.
Fraser, Sarah
Boer, Jennifer C.
Plebanski, Magdalena
de Courten, Barbora
Apostolopoulos, Vasso
Anti-Cancer Effects of Carnosine—A Dipeptide Molecule
title Anti-Cancer Effects of Carnosine—A Dipeptide Molecule
title_full Anti-Cancer Effects of Carnosine—A Dipeptide Molecule
title_fullStr Anti-Cancer Effects of Carnosine—A Dipeptide Molecule
title_full_unstemmed Anti-Cancer Effects of Carnosine—A Dipeptide Molecule
title_short Anti-Cancer Effects of Carnosine—A Dipeptide Molecule
title_sort anti-cancer effects of carnosine—a dipeptide molecule
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002160/
https://www.ncbi.nlm.nih.gov/pubmed/33809496
http://dx.doi.org/10.3390/molecules26061644
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