High-Throughput Screening for CEBPD-Modulating Compounds in THP-1-Derived Reporter Macrophages Identifies Anti-Inflammatory HDAC and BET Inhibitors

This study aimed to identify alternative anti-inflammatory compounds that modulate the activity of a relevant transcription factor, CCAAT/enhancer binding protein delta (C/EBPδ). C/EBPδ is a master regulator of inflammatory responses in macrophages (Mϕ) and is mainly regulated at the level of CEBPD...

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Detalles Bibliográficos
Autores principales: Ullmann, Tatjana, Luckhardt, Sonja, Wolf, Markus, Parnham, Michael J., Resch, Eduard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002291/
https://www.ncbi.nlm.nih.gov/pubmed/33809617
http://dx.doi.org/10.3390/ijms22063022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002291/
https://www.ncbi.nlm.nih.gov/pubmed/33809617
http://dx.doi.org/10.3390/ijms22063022

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