Molecular Basis of AmpC β-Lactamase Induction by Avibactam in Pseudomonas aeruginosa: PBP Occupancy, Live Cell Binding Dynamics and Impact on Resistant Clinical Isolates Harboring PDC-X Variants

Avibactam belongs to the new class of diazabicyclooctane β-lactamase inhibitors. Its inhibitory spectrum includes class A, C and D enzymes, including P. aeruginosa AmpC. Nonetheless, recent reports have revealed strain-dependent avibactam AmpC induction. In the present work, we wanted to assess the...

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Detalles Bibliográficos
Autores principales: López-Argüello, Silvia, Montaner, María, Oliver, Antonio, Moya, Bartolome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002452/
https://www.ncbi.nlm.nih.gov/pubmed/33802668
http://dx.doi.org/10.3390/ijms22063051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002452/
https://www.ncbi.nlm.nih.gov/pubmed/33802668
http://dx.doi.org/10.3390/ijms22063051

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