Autocrine TGFβ1 Opposes Exogenous TGFβ1-Induced Cell Migration and Growth Arrest through Sustainment of a Feed-Forward Loop Involving MEK-ERK Signaling

SIMPLE SUMMARY: Transforming growth factor (TGF) β signaling is intimately involved in nearly all aspects of tumor development and is known for its role as both a tumor suppressor in benign tissues and a tumor promoter in advanced cancers. This dual role is also reflected by cancer cell-produced TGF...

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Detalles Bibliográficos
Autores principales: Ungefroren, Hendrik, Christl, Jessica, Eiden, Caroline, Wellner, Ulrich F., Lehnert, Hendrik, Marquardt, Jens-Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002526/
https://www.ncbi.nlm.nih.gov/pubmed/33802809
http://dx.doi.org/10.3390/cancers13061357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002526/
https://www.ncbi.nlm.nih.gov/pubmed/33802809
http://dx.doi.org/10.3390/cancers13061357

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