Synthesis and Structure–Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research

Epigenetic regulation is known to play a key role in progression of anti-cancer therapeutics. Lysine acetylation is an important mechanism in controlling gene expression. There has been increasing interest in bromodomain owing to its ability to modulate transcription of various genes as an epigeneti...

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Detalles Bibliográficos
Autores principales: Yoo, Minjin, Park, Tae Hyun, Yoo, Miyoun, Kim, Yeongrin, Lee, Joo-Youn, Lee, Kyu Myung, Ryu, Seong Eon, Lee, Byung Il, Jung, Kwan-Young, Park, Chi Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002823/
https://www.ncbi.nlm.nih.gov/pubmed/33802888
http://dx.doi.org/10.3390/molecules26061686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002823/
https://www.ncbi.nlm.nih.gov/pubmed/33802888
http://dx.doi.org/10.3390/molecules26061686

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