Structure-Based Virtual Screening and De Novo Design of PIM1 Inhibitors with Anticancer Activity from Natural Products

Background: the proviral insertion site of Moloney murine leukemia (PIM) 1 kinase has served as a therapeutic target for various human cancers due to the enhancement of cell proliferation and the inhibition of apoptosis. Methods: to identify effective PIM1 kinase inhibitors, structure-based virtual...

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Detalles Bibliográficos
Autores principales: Park, Hwangseo, Jeon, Jinwon, Kim, Kewon, Choi, Soyeon, Hong, Sungwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003278/
https://www.ncbi.nlm.nih.gov/pubmed/33803840
http://dx.doi.org/10.3390/ph14030275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003278/
https://www.ncbi.nlm.nih.gov/pubmed/33803840
http://dx.doi.org/10.3390/ph14030275

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