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Structure-Based Virtual Screening and De Novo Design of PIM1 Inhibitors with Anticancer Activity from Natural Products

Background: the proviral insertion site of Moloney murine leukemia (PIM) 1 kinase has served as a therapeutic target for various human cancers due to the enhancement of cell proliferation and the inhibition of apoptosis. Methods: to identify effective PIM1 kinase inhibitors, structure-based virtual...

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Detalles Bibliográficos
Autores principales:	Park, Hwangseo, Jeon, Jinwon, Kim, Kewon, Choi, Soyeon, Hong, Sungwoo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003278/ https://www.ncbi.nlm.nih.gov/pubmed/33803840 http://dx.doi.org/10.3390/ph14030275

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