Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives

Phenylketonuria (PKU) is a genetic disease caused by deficient activity of human phenylalanine hydroxylase (hPAH) that, when untreated, can lead to severe psychomotor impairment. Protein misfolding is recognized as the main underlying pathogenic mechanism of PKU. Therefore, the use of stabilizers of...

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Detalles Bibliográficos
Autores principales: Lopes, Raquel R., Tomé, Catarina S., Russo, Roberto, Paterna, Roberta, Leandro, João, Candeias, Nuno R., Gonçalves, Lídia M. D., Teixeira, Miguel, Sousa, Pedro M. F., Guedes, Rita C., Vicente, João B., Gois, Pedro M. P., Leandro, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003416/
https://www.ncbi.nlm.nih.gov/pubmed/33808760
http://dx.doi.org/10.3390/biom11030462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003416/
https://www.ncbi.nlm.nih.gov/pubmed/33808760
http://dx.doi.org/10.3390/biom11030462

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