Alternative Non-Homologous End-Joining: Error-Prone DNA Repair as Cancer’s Achilles’ Heel

SIMPLE SUMMARY: Cancer onset and progression lead to a high rate of DNA damage, due to replicative and metabolic stress. To survive in this dangerous condition, cancer cells switch the DNA repair machinery from faithful systems to error-prone pathways, strongly increasing the mutational rate that, i...

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Detalles Bibliográficos
Autores principales: Caracciolo, Daniele, Riillo, Caterina, Di Martino, Maria Teresa, Tagliaferri, Pierosandro, Tassone, Pierfrancesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003480/
https://www.ncbi.nlm.nih.gov/pubmed/33808562
http://dx.doi.org/10.3390/cancers13061392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003480/
https://www.ncbi.nlm.nih.gov/pubmed/33808562
http://dx.doi.org/10.3390/cancers13061392

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