Synthesis and Evaluation of Novel α-Aminoamides Containing Benzoheterocyclic Moiety for the Treatment of Pain

Novel α-aminoamide derivatives containing different benzoheterocyclics moiety were synthesized and evaluated as voltage-gated sodium ion channels blocks the treatment of pain. Compounds 6a, 6e, and 6f containing the benzofuran group displayed more potent in vivo analgesic activity than ralfinamide i...

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Detalles Bibliográficos
Autores principales: Tong, Kun, Zhang, Ruotian, Ren, Fengzhi, Zhang, Tao, He, Junlin, Cheng, Jingchao, Yu, Zixing, Ren, Fengxia, Zhang, Yatong, Shi, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003485/
https://www.ncbi.nlm.nih.gov/pubmed/33808667
http://dx.doi.org/10.3390/molecules26061716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003485/
https://www.ncbi.nlm.nih.gov/pubmed/33808667
http://dx.doi.org/10.3390/molecules26061716

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