Parallel G-quadruplex Structures Increase Cellular Uptake and Cytotoxicity of 5-Fluoro-2′-deoxyuridine Oligomers in 5-Fluorouracil Resistant Cells

Fluoropyrimidines, such as 5-fluorouracil (5-FU) and related prodrugs have been considered first-line chemotherapy agents for the treatment of colorectal cancer. However, poor specificity and tumor cell resistance remain major limiting bottlenecks. G-quadruplexes, have been suggested as preferred na...

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Detalles Bibliográficos
Autores principales: Clua, Anna, Fàbrega, Carme, García-Chica, Jesús, Grijalvo, Santiago, Eritja, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003610/
https://www.ncbi.nlm.nih.gov/pubmed/33804620
http://dx.doi.org/10.3390/molecules26061741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003610/
https://www.ncbi.nlm.nih.gov/pubmed/33804620
http://dx.doi.org/10.3390/molecules26061741

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