Cargando…

Parallel G-quadruplex Structures Increase Cellular Uptake and Cytotoxicity of 5-Fluoro-2′-deoxyuridine Oligomers in 5-Fluorouracil Resistant Cells

Fluoropyrimidines, such as 5-fluorouracil (5-FU) and related prodrugs have been considered first-line chemotherapy agents for the treatment of colorectal cancer. However, poor specificity and tumor cell resistance remain major limiting bottlenecks. G-quadruplexes, have been suggested as preferred na...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clua, Anna, Fàbrega, Carme, García-Chica, Jesús, Grijalvo, Santiago, Eritja, Ramon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003610/ https://www.ncbi.nlm.nih.gov/pubmed/33804620 http://dx.doi.org/10.3390/molecules26061741

Ejemplares similares

Exploring the Interaction of Curaxin CBL0137 with G-Quadruplex DNA Oligomers
por: Dallavalle, Sabrina, et al.
Publicado: (2021)

Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells
por: Matsumoto, Yoshihiro, et al.
Publicado: (2015)

Tuning G-Quadruplex Nanostructures with Lipids. Towards Designing Hybrid Scaffolds for Oligonucleotide Delivery †
por: Grijalvo, Santiago, et al.
Publicado: (2020)

Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes
por: Clua, Anna, et al.
Publicado: (2022)

Evaluation of Floxuridine Oligonucleotide Conjugates Carrying Potential Enhancers of Cellular Uptake
por: Aviñó, Anna, et al.
Publicado: (2021)

Correction: Clua et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules 2022, 27, 3944
por: Clua, Anna, et al.
Publicado: (2022)

5-fluorouracil and 5-fluoro-2'-deoxyuridine follow different metabolic pathways in the induction of cell lethality in L1210 leukaemia.
por: Roobol, C., et al.
Publicado: (1984)

Development of modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity
por: Wu, Shao-yu, et al.
Publicado: (2013)

Thioctic Acid Derivatives as Building Blocks to Incorporate DNA Oligonucleotides onto Gold Nanoparticles
por: Pérez-Rentero, Sónia, et al.
Publicado: (2014)

Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers
por: Ferreira, Rubén, et al.
Publicado: (2010)

Cellular pharmacology of multi- and duplex drugsconsisting of ethynylcytidine and 5-fluoro-2′-deoxyuridine
por: Bijnsdorp, Irene V., et al.
Publicado: (2009)

Lipid and Peptide-Oligonucleotide Conjugates for Therapeutic Purposes: From Simple Hybrids to Complex Multifunctional Assemblies
por: Fàbrega, Carme, et al.
Publicado: (2023)

Incorporation of 5-Bromo-2′-deoxyuridine into DNA and Proliferative Behavior of Cerebellar Neuroblasts: All That Glitters Is Not Gold
por: Martí-Clúa, Joaquín
Publicado: (2021)

5-Bromo-2’-deoxyuridine labeling: historical perspectives, factors influencing the detection, toxicity, and its implications in the neurogenesis
por: Martí-Clúa, Joaquín
Publicado: (2023)

Synthesis and properties of DNA oligomers containing stereopure phosphorothioate linkages and C-5 modified deoxyuridine derivatives
por: Hara, Rintaro Iwata, et al.
Publicado: (2020)

Synthesis of 2′-O-Methyl/2′-O-MOE-L-Nucleoside Derivatives and Their Applications: Preparation of G-Quadruplexes, Their Characterization, and Stability Studies
por: Martín-Nieves, Virginia, et al.
Publicado: (2023)

5-Selenocyanato and 5-trifluoromethanesulfonyl derivatives of 2′-deoxyuridine: synthesis, radiation and computational chemistry as well as cytotoxicity
por: Makurat, Samanta, et al.
Publicado: (2018)

In vivo uptake of 131I-5-iodo-2-deoxyuridine by malignant tumours in man.
por: Philip, P. A., et al.
Publicado: (1991)

Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase.
por: Patterson, A. V., et al.
Publicado: (1995)

MicroRNA-351 Regulates Two-Types of Cell Death, Necrosis and Apoptosis, Induced by 5-fluoro-2'-deoxyuridine
por: Sato, Akira, et al.
Publicado: (2016)

Folic Acid-Metabolizing Enzymes Regulate the Antitumor Effect of 5-Fluoro-2′-Deoxyuridine in Colorectal Cancer Cell Lines
por: Tsukihara, Hiroshi, et al.
Publicado: (2016)

DNA triplex formation with 5-dimethylaminopropargyl deoxyuridine
por: Rusling, David A., et al.
Publicado: (2009)

Evaluating the Genotoxic and Cytotoxic Effects of Thymidine Analogs, 5-Ethynyl-2′-Deoxyuridine and 5-Bromo-2′-Deoxyurdine to Mammalian Cells
por: Haskins, Jeremy S., et al.
Publicado: (2020)

Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2′-deoxyuridine-5′-monophosphate on ABCC11 in silico models
por: Honorat, Mylène, et al.
Publicado: (2013)

Diesterified Derivatives of 5-Iodo-2′-Deoxyuridine as Cerebral Tumor Tracers
por: Rösler, Thomas W., et al.
Publicado: (2014)

Influence of Hypoxia on Radiosensitization of Cancer Cells by 5-Bromo-2′-deoxyuridine
por: Zdrowowicz, Magdalena, et al.
Publicado: (2022)

Development of a Novel Fluorescence Assay Based on the Use of the Thrombin-Binding Aptamer for the Detection of O(6)-Alkylguanine-DNA Alkyltransferase Activity
por: Tintoré, Maria, et al.
Publicado: (2010)

The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2′-Deoxyuridine and Tubercidin Analogues
por: Aldfer, Mustafa M., et al.
Publicado: (2022)

On the Race for More Stretchable and Tough Hydrogels
por: Grijalvo, Santiago, et al.
Publicado: (2019)

G-Quadruplex Nucleic Acids
por: Eritja, Ramon, et al.
Publicado: (2010)

Monitoring DNA replication in fission yeast by incorporation of 5-ethynyl-2′-deoxyuridine
por: Hua, Hui, et al.
Publicado: (2011)

Crystal structure of 5-(dibenzofuran-4-yl)-2′-deoxyuridine
por: Gayakhe, Vijay, et al.
Publicado: (2017)

Radiosensitization of PC3 Prostate Cancer Cells by 5-Thiocyanato-2′-deoxyuridine
por: Zdrowowicz, Magdalena, et al.
Publicado: (2022)

Cytotoxicity and radiosensitising activity of synthesized dinitrophenyl derivatives of 5-fluorouracil
por: Abdi, Khosrou, et al.
Publicado: (2012)

Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase
por: Nakamura, Ayako, et al.
Publicado: (2013)

Variable-Temperature Size Exclusion Chromatography for the Study of the Structural Changes in G-Quadruplex
por: Benabou, Sanae, et al.
Publicado: (2013)

The Herb–Drug Pharmacokinetic Interaction of 5-Fluorouracil and Its Metabolite 5-Fluoro-5,6-Dihydrouracil with a Traditional Chinese Medicine in Rats
por: Liu, Ju-Han, et al.
Publicado: (2017)

Influence of pH on the uptake of 5-fluorouracil into isolated tumour cells.
por: Ojugo, A. S., et al.
Publicado: (1998)

The antibodies against 5-bromo-2′-deoxyuridine specifically recognize trifluridine incorporated into DNA
por: Kitao, Hiroyuki, et al.
Publicado: (2016)

C5-Azobenzene-substituted 2'-Deoxyuridine-containing Oligodeoxynucleotides for Photo-Switching Hybridization
por: Mori, Shohei, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_up47ce3fvb6th6mkri1vnjfkk6