Evidence for additive and synergistic action of mammalian enhancers during cell fate determination

Enhancer activity drives cell differentiation and cell fate determination, but it remains unclear how enhancers cooperate during these processes. Here we investigate enhancer cooperation during transdifferentiation of human leukemia B-cells to macrophages. Putative enhancers are established by bindi...

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Detalles Bibliográficos
Autores principales: Choi, Jinmi, Lysakovskaia, Kseniia, Stik, Gregoire, Demel, Carina, Söding, Johannes, Tian, Tian V, Graf, Thomas, Cramer, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004103/
https://www.ncbi.nlm.nih.gov/pubmed/33770473
http://dx.doi.org/10.7554/eLife.65381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004103/
https://www.ncbi.nlm.nih.gov/pubmed/33770473
http://dx.doi.org/10.7554/eLife.65381

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