A Cystine-Cysteine Intercellular Shuttle Prevents Ferroptosis in xCT(KO) Pancreatic Ductal Adenocarcinoma Cells

SIMPLE SUMMARY: The xCT transporter of oxidized form of cysteine has been recognized as fundamental for cellular amino acid and redox homeostasis. Increasing number of data suggests that xCT inhibition-induced ferroptosis has great potential for development of novel anti-cancer therapeutics for panc...

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Detalles Bibliográficos
Autores principales: Meira, Willian, Daher, Boutaina, Parks, Scott Kenneth, Cormerais, Yann, Durivault, Jerome, Tambutte, Eric, Pouyssegur, Jacques, Vučetić, Milica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004104/
https://www.ncbi.nlm.nih.gov/pubmed/33801101
http://dx.doi.org/10.3390/cancers13061434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004104/
https://www.ncbi.nlm.nih.gov/pubmed/33801101
http://dx.doi.org/10.3390/cancers13061434

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