A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism

BACKGROUND: Cancer cells drastically increase the uptake of glucose and glucose metabolism by overexpressing class I glucose transporters (GLUT1-4) to meet their energy and biomass synthesis needs and are very sensitive and vulnerable to glucose deprivation. Although targeting glucose uptake via GLU...

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Detalles Bibliográficos
Autores principales: Shriwas, Pratik, Roberts, Dennis, Li, Yunsheng, Wang, Liyi, Qian, Yanrong, Bergmeier, Stephen, Hines, Jennifer, Adhicary, Subhodip, Nielsen, Corinne, Chen, Xiaozhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004435/
https://www.ncbi.nlm.nih.gov/pubmed/33771231
http://dx.doi.org/10.1186/s40170-021-00248-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004435/
https://www.ncbi.nlm.nih.gov/pubmed/33771231
http://dx.doi.org/10.1186/s40170-021-00248-7

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