Improved Diazo-Transfer Reaction for DNA-Encoded Chemistry and Its Potential Application for Macrocyclic DEL-Libraries

DNA-encoded libraries (DEL) are increasingly being used to identify new starting points for medicinal chemistry in drug discovery. Herein, we discuss the development of methods that allow the conversion of both primary amines and anilines, attached to DNA, to their corresponding azides in excellent...

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Detalles Bibliográficos
Autores principales: Ede, Selahattin, Schenk, Mandy, Bierer, Donald, Weinmann, Hilmar, Graham, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004608/
https://www.ncbi.nlm.nih.gov/pubmed/33810133
http://dx.doi.org/10.3390/molecules26061790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004608/
https://www.ncbi.nlm.nih.gov/pubmed/33810133
http://dx.doi.org/10.3390/molecules26061790

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