Whole-Body Pharmacokinetics and Physiologically Based Pharmacokinetic Model for Monomethyl Auristatin E (MMAE)

Monomethyl auristatin E (MMAE) is one of the most commonly used payloads for developing antibody–drug conjugates (ADC). However, limited studies have comprehensively evaluated the whole-body disposition of MMAE. Consequently, here, we have investigated the whole-body pharmacokinetics (PK) of MMAE in...

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Detalles Bibliográficos
Autores principales: Chang, Hsuan Ping, Cheung, Yuen Kiu, Shah, Dhaval K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004929/
https://www.ncbi.nlm.nih.gov/pubmed/33807057
http://dx.doi.org/10.3390/jcm10061332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004929/
https://www.ncbi.nlm.nih.gov/pubmed/33807057
http://dx.doi.org/10.3390/jcm10061332

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