Cargando…

The GNAQ T96S Mutation Affects Cell Signaling and Enhances the Oncogenic Properties of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC), the most common malignant tumor in the liver, grows and metastasizes rapidly. Despite advances in treatment modalities, the five-year survival rate of HCC remains less than 30%. We sought genetic mutations that may affect the oncogenic properties of HCC, using The Can...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Eugene, Park, Sung Jean, Lee, Gunhee, Yoon, Seung Kew, Lee, Minho, Lee, Suk Kyeong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004934/ https://www.ncbi.nlm.nih.gov/pubmed/33807071 http://dx.doi.org/10.3390/ijms22063284

Ejemplares similares

Recurrent GNAQ mutation encoding T96S in natural killer/T cell lymphoma
por: Li, Zhaoming, et al.
Publicado: (2019)

Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11
por: Koopmans, A E, et al.
Publicado: (2013)

Oncogenic GNAQ and GNA11 Mutations in Uveal Melanoma in Chinese
por: Xu, Xiaolin, et al.
Publicado: (2014)

GNAQ T96S mutation abrogates the ability of wild‐type GNAQ to induce apoptosis by phosphorylating annexin A2 in natural killer/T cell lymphoma
por: Zhao, Wugan, et al.
Publicado: (2022)

Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma
por: Bauer, J, et al.
Publicado: (2009)

Crosstalk with keratinocytes causes GNAQ oncogene specificity in melanoma
por: Urtatiz, Oscar, et al.
Publicado: (2021)

GNAQ knockdown promotes bone metastasis through epithelial-mesenchymal transition in lung cancer cells
por: Choi, Ji-Yoon, et al.
Publicado: (2021)

Effect of GNAQ alteration on RANKL-induced osteoclastogenesis in human non-small-cell lung cancer
por: Choi, Ji-Yoon, et al.
Publicado: (2020)

Mutational Profile of GNAQ (Q209) in Human Tumors
por: Lamba, Simona, et al.
Publicado: (2009)

GNAQ mutation in a patient with metastatic mucosal melanoma
por: Kim, Chung-Young, et al.
Publicado: (2014)

BRAF, NRAS, and GNAQ Mutations in Conjunctival Melanocytic Nevi
por: Francis, Jasmine H., et al.
Publicado: (2018)

Classification of Genes Based on Age-Related Differential Expression in Breast Cancer
por: Lee, Gunhee, et al.
Publicado: (2017)

Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking
por: Lee, In Won, et al.
Publicado: (2017)

Frequent somatic mutations of GNAQ in uveal melanoma and blue nevi
por: Van Raamsdonk, Catherine D., et al.
Publicado: (2008)

Somatic GNAQ mutation in the forme fruste of Sturge-Weber syndrome
por: Hildebrand, Michael S., et al.
Publicado: (2018)

Mutation spectrum in GNAQ and GNA11 in Chinese uveal melanoma
por: Zhang, Edward D, et al.
Publicado: (2019)

MITF deficiency and oncogenic GNAQ each promote proliferation programs in zebrafish melanocyte lineage cells
por: Phelps, Grace B., et al.
Publicado: (2022)

Misaligned sequencing reads from the GNAQ-pseudogene locus may yield GNAQ artefact variants
por: Lim, Jing Quan, et al.
Publicado: (2022)

Structural Analysis of Recombinant Human Preproinsulins by Structure Prediction, Molecular Dynamics, and Protein-Protein Docking
por: Jung, Sung Hun, et al.
Publicado: (2017)

GNAQ and GNA11 mutations and downstream YAP activation in choroidal nevi
por: Vader, M J C, et al.
Publicado: (2017)

Klippel–Trenaunay and Sturge–Weber Overlap Syndrome with KRAS and GNAQ mutations
por: He, Ruojie, et al.
Publicado: (2020)

GNAQ Q209R Mutations Are Highly Specific for Circumscribed Choroidal Hemangioma
por: Le Guin, Claudia Helga Dorothee, et al.
Publicado: (2019)

YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations
por: Lyubasyuk, Vera, et al.
Publicado: (2014)

Gnaq(M1J): An ENU induced mutant allele affecting pigmentation in the mouse
por: Pratt, C. Herbert, et al.
Publicado: (2016)

Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma?
por: van Weeghel, Christiaan, et al.
Publicado: (2019)

BRAF, GNAQ, and GNA11 mutations and copy number in pediatric low-grade glioma
por: Laviv, Yosef, et al.
Publicado: (2012)

Gnaq and Gna11 in the Endothelin Signaling Pathway and Melanoma
por: Urtatiz, Oscar, et al.
Publicado: (2016)

MITF deficiency accelerates GNAQ-driven uveal melanoma
por: Phelps, Grace B., et al.
Publicado: (2022)

Distribution of GNAQ and GNA11 Mutation Signatures in Uveal Melanoma Points to a Light Dependent Mutation Mechanism
por: de Lange, Mark J., et al.
Publicado: (2015)

Improved discrimination of melanotic schwannoma from melanocytic lesions by combined morphological and GNAQ mutational analysis
por: Küsters-Vandevelde, Heidi V. N., et al.
Publicado: (2010)

GNAQ and BRAF mutations show differential activation of the mTOR pathway in human transformed cells
por: Pópulo, Helena, et al.
Publicado: (2013)

Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis
por: Thomas, Anna C., et al.
Publicado: (2016)

GNA14, GNA11, and GNAQ Mutations Are Frequent in Benign but Not Malignant Cutaneous Vascular Tumors
por: Jansen, Philipp, et al.
Publicado: (2021)

Immunological Markers, Prognostic Factors and Challenges Following Curative Treatments for Hepatocellular Carcinoma
por: Lee, Soon Kyu, et al.
Publicado: (2021)

Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system
por: Küsters-Vandevelde, Heidi V. N., et al.
Publicado: (2009)

Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQ(Q209P)-driven uveal melanomas in zebrafish
por: Mouti, Mai Abdel, et al.
Publicado: (2016)

Lack of GNAQ and GNA11 Germ-Line Mutations in Familial Melanoma Pedigrees with Uveal Melanoma or Blue Nevi
por: Hawkes, Jason E., et al.
Publicado: (2013)

BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells
por: Ambrosini, Grazia, et al.
Publicado: (2015)

Case Report: GNAQ- and SF3B1 Mutations in an Aggressive Case of Relapsing Uveal Ring Melanoma
por: Prasuhn, Michelle, et al.
Publicado: (2022)

Somatic GNAQ R183Q mutation is located within the sclera and episclera in patients with Sturge-Weber syndrome
por: Wu, Yue, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6ibk1tetcbujfrk40uohkh7it0