Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution

Affibody molecules hold great promise as carriers of cytotoxic drugs for cancer therapy due to their typically high affinity, easy production, and inherent control of the drug molecules’ loading and spatial arrangement. Here, the impact of increasing the drug load from one to three on the properties...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Haozhong, Xu, Tianqi, Zhang, Jie, Tolmachev, Vladimir, Oroujeni, Maryam, Orlova, Anna, Gräslund, Torbjörn, Vorobyeva, Anzhelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005000/
https://www.ncbi.nlm.nih.gov/pubmed/33806887
http://dx.doi.org/10.3390/pharmaceutics13030430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005000/
https://www.ncbi.nlm.nih.gov/pubmed/33806887
http://dx.doi.org/10.3390/pharmaceutics13030430

Ejemplares similares