A Novel Graph Neural Network Methodology to Investigate Dihydroorotate Dehydrogenase Inhibitors in Small Cell Lung Cancer

Small cell lung cancer (SCLC) is a particularly aggressive tumor subtype, and dihydroorotate dehydrogenase (DHODH) has been demonstrated to be a therapeutic target for SCLC. Network pharmacology analysis and virtual screening were utilized to find out related proteins and investigate candidates with...

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Detalles Bibliográficos
Autores principales: Zhi, Hong-Yi, Zhao, Lu, Lee, Cheng-Chun, Chen, Calvin Yu-Chian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005042/
https://www.ncbi.nlm.nih.gov/pubmed/33806898
http://dx.doi.org/10.3390/biom11030477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005042/
https://www.ncbi.nlm.nih.gov/pubmed/33806898
http://dx.doi.org/10.3390/biom11030477

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