Low Adenovirus Vaccine Doses Administered to Skin Using Microneedle Patches Induce Better Functional Antibody Immunogenicity as Compared to Systemic Injection

Adenovirus-based vaccines are demonstrating promising clinical potential for multiple infectious diseases, including COVID-19. However, the immunogenicity of the vector itself decreases its effectiveness as a boosting vaccine due to the induction of strong anti-vector neutralizing immunity. Here we...

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Detalles Bibliográficos
Autores principales: Flynn, Olivia, Dillane, Kate, Lanza, Juliane Sousa, Marshall, Jennifer M., Jin, Jing, Silk, Sarah E., Draper, Simon J., Moore, Anne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005075/
https://www.ncbi.nlm.nih.gov/pubmed/33810085
http://dx.doi.org/10.3390/vaccines9030299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005075/
https://www.ncbi.nlm.nih.gov/pubmed/33810085
http://dx.doi.org/10.3390/vaccines9030299

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