Low-Dose Decitabine Augments the Activation and Anti-Tumor Immune Response of IFN-γ(+) CD4(+) T Cells Through Enhancing IκBα Degradation and NF-κB Activation

BACKGROUND: CD4(+) T cells play multiple roles in controlling tumor growth and increasing IFN-γ(+) T-helper 1 cell population could promote cell-mediated anti-tumor immune response. We have previously showed that low-dose DNA demethylating agent decitabine therapy promotes CD3(+) T-cell proliferatio...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Dong, Liang, Liu, Jiejie, Wang, Chunmeng, Zhang, Yan, Mei, Qian, Han, Weidong, Xie, Ping, Nie, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005576/
https://www.ncbi.nlm.nih.gov/pubmed/33791306
http://dx.doi.org/10.3389/fcell.2021.647713

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005576/
https://www.ncbi.nlm.nih.gov/pubmed/33791306
http://dx.doi.org/10.3389/fcell.2021.647713

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