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Low-Dose Decitabine Augments the Activation and Anti-Tumor Immune Response of IFN-γ(+) CD4(+) T Cells Through Enhancing IκBα Degradation and NF-κB Activation
BACKGROUND: CD4(+) T cells play multiple roles in controlling tumor growth and increasing IFN-γ(+) T-helper 1 cell population could promote cell-mediated anti-tumor immune response. We have previously showed that low-dose DNA demethylating agent decitabine therapy promotes CD3(+) T-cell proliferatio...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005576/ https://www.ncbi.nlm.nih.gov/pubmed/33791306 http://dx.doi.org/10.3389/fcell.2021.647713 |