Pharmacologic Inhibition of ADAM10 Attenuates Brain Tissue Loss, Axonal Injury and Pro-inflammatory Gene Expression Following Traumatic Brain Injury in Mice

The α-secretase A disintegrin and metalloprotease 10 (ADAM10) regulates various physiological and pathophysiological processes. Despite its broad functional implications during development, plasticity, and disease, no pharmacological approaches to inhibit ADAM10 in acute brain injury have been repor...

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Detalles Bibliográficos
Autores principales: Appel, Dominik, Hummel, Regina, Weidemeier, Martin, Endres, Kristina, Gölz, Christina, Schäfer, Michael K. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005610/
https://www.ncbi.nlm.nih.gov/pubmed/33791311
http://dx.doi.org/10.3389/fcell.2021.661462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005610/
https://www.ncbi.nlm.nih.gov/pubmed/33791311
http://dx.doi.org/10.3389/fcell.2021.661462

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