The PI3K∂-Selective Inhibitor Idelalisib Induces T- and NK-Cell Dysfunction Independently of B-Cell Malignancy-Associated Immunosuppression

B-cell receptors, multiple receptor tyrosine kinases, and downstream effectors are constitutively active in chronic lymphocytic leukemia (CLL) B cells. Activation of these pathways results in resistance to apoptosis and enhanced survival of the leukemic cells. Idelalisib is a highly selective inhibi...

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Detalles Bibliográficos
Autores principales: Rohrbacher, Lisa, Brauchle, Bettina, Ogrinc Wagner, Ana, von Bergwelt-Baildon, Michael, Bücklein, Veit L., Subklewe, Marion
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005712/
https://www.ncbi.nlm.nih.gov/pubmed/33790890
http://dx.doi.org/10.3389/fimmu.2021.608625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005712/
https://www.ncbi.nlm.nih.gov/pubmed/33790890
http://dx.doi.org/10.3389/fimmu.2021.608625

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