A Human RNA Viral Cysteine Proteinase That Depends upon a Unique Zn(2+)-binding Finger Connecting the Two Domains of a Papain-like Fold

A cysteine proteinase, papain-like proteinase (PL1pro), of the human coronavirus 229E (HCoV) regulates the expression of the replicase polyproteins, pp1a and ppa1ab, by cleavage between Gly(111) and Asn(112), far upstream of its own catalytic residue Cys(1054). In this report, using bioinformatics t...

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Detalles Bibliográficos
Autores principales: Herold, Jens, Siddell, Stuart G., Gorbalenya, Alexander E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. 1999
Materias:
Protein Chemistry and Structure
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005983/
https://www.ncbi.nlm.nih.gov/pubmed/10329692
http://dx.doi.org/10.1074/jbc.274.21.14918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005983/
https://www.ncbi.nlm.nih.gov/pubmed/10329692
http://dx.doi.org/10.1074/jbc.274.21.14918

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