Membrane Interactions of α-Synuclein Revealed by Multiscale Molecular Dynamics Simulations, Markov State Models, and NMR

[Image: see text] α-Synuclein (αS) is a presynaptic protein that binds to cell membranes and is linked to Parkinson’s disease (PD). Binding of αS to membranes is a likely first step in the molecular pathophysiology of PD. The αS molecule can adopt multiple conformations, being largely disordered in...

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Detalles Bibliográficos
Autores principales: Amos, Sarah-Beth T. A., Schwarz, Thomas C., Shi, Jiye, Cossins, Benjamin P., Baker, Terry S., Taylor, Richard J., Konrat, Robert, Sansom, Mark S. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006134/
https://www.ncbi.nlm.nih.gov/pubmed/33719460
http://dx.doi.org/10.1021/acs.jpcb.1c01281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006134/
https://www.ncbi.nlm.nih.gov/pubmed/33719460
http://dx.doi.org/10.1021/acs.jpcb.1c01281

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