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Membrane Interactions of α-Synuclein Revealed by Multiscale Molecular Dynamics Simulations, Markov State Models, and NMR
[Image: see text] α-Synuclein (αS) is a presynaptic protein that binds to cell membranes and is linked to Parkinson’s disease (PD). Binding of αS to membranes is a likely first step in the molecular pathophysiology of PD. The αS molecule can adopt multiple conformations, being largely disordered in...
Autores principales: | Amos, Sarah-Beth T. A., Schwarz, Thomas C., Shi, Jiye, Cossins, Benjamin P., Baker, Terry S., Taylor, Richard J., Konrat, Robert, Sansom, Mark S. P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006134/ https://www.ncbi.nlm.nih.gov/pubmed/33719460 http://dx.doi.org/10.1021/acs.jpcb.1c01281 |
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