Nanoparticle-Mediated Lipid Metabolic Reprogramming of T Cells in Tumor Microenvironments for Immunometabolic Therapy

HIGHLIGHTS: aCD3/F/AN, anti-CD3e f(ab′)2 fragment-modified and fenofibrate-encapsulated amphiphilic nanoparticle, reprogrammed mitochondrial lipid metabolism of T cells. aCD3/F/AN specifically activated T cells in glucose-deficient conditions mimicking tumor microenvironment, and exerted an effector...

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Detalles Bibliográficos
Autores principales: Kim, Dongyoon, Wu, Yina, Li, Qiaoyun, Oh, Yu-Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006499/
https://www.ncbi.nlm.nih.gov/pubmed/34138236
http://dx.doi.org/10.1007/s40820-020-00555-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006499/
https://www.ncbi.nlm.nih.gov/pubmed/34138236
http://dx.doi.org/10.1007/s40820-020-00555-6

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