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A heterochromatin inducing protein differentially recognizes self versus foreign genomes
Krüppel-associated box-domain zinc finger protein (KRAB-ZFP) transcriptional repressors recruit TRIM28/KAP1 to heterochromatinize the mammalian genome while also guarding the host by silencing invading foreign genomes. However, how a KRAB-ZFP recognizes target sequences in the natural context of its...
Autores principales: | Burton, Eric M., Akinyemi, Ibukun A., Frey, Tiffany R., Xu, Huanzhou, Li, Xiaofan, Su, Lai Jing, Zhi, Jizu, McIntosh, Michael T., Bhaduri-McIntosh, Sumita |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007004/ https://www.ncbi.nlm.nih.gov/pubmed/33730092 http://dx.doi.org/10.1371/journal.ppat.1009447 |
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