Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase

[Image: see text] SH2 domain-containing tyrosine phosphatase 2 (SHP2), encoded by PTPN11, plays a fundamental role in the modulation of several signaling pathways. Germline and somatic mutations in PTPN11 are associated with different rare diseases and hematologic malignancies, and recent studies ha...

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Detalles Bibliográficos
Autores principales: Anselmi, Massimiliano, Calligari, Paolo, Hub, Jochen S., Tartaglia, Marco, Bocchinfuso, Gianfranco, Stella, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007070/
https://www.ncbi.nlm.nih.gov/pubmed/32395997
http://dx.doi.org/10.1021/acs.jcim.0c00307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007070/
https://www.ncbi.nlm.nih.gov/pubmed/32395997
http://dx.doi.org/10.1021/acs.jcim.0c00307

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