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Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase

[Image: see text] SH2 domain-containing tyrosine phosphatase 2 (SHP2), encoded by PTPN11, plays a fundamental role in the modulation of several signaling pathways. Germline and somatic mutations in PTPN11 are associated with different rare diseases and hematologic malignancies, and recent studies ha...

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Detalles Bibliográficos
Autores principales:	Anselmi, Massimiliano, Calligari, Paolo, Hub, Jochen S., Tartaglia, Marco, Bocchinfuso, Gianfranco, Stella, Lorenzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007070/ https://www.ncbi.nlm.nih.gov/pubmed/32395997 http://dx.doi.org/10.1021/acs.jcim.0c00307

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