Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy

[Image: see text] Human carbonic anhydrase (CA; EC 4.2.1.1) isoforms II and VII are implicated in neuronal excitation, seizures, and neuropathic pain (NP). Their selective inhibition over off-target CAs is expected to produce an anti-NP action devoid of side effects due to promiscuous CA modulation....

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Detalles Bibliográficos
Autores principales: Nocentini, Alessio, Alterio, Vincenzo, Bua, Silvia, Micheli, Laura, Esposito, Davide, Buonanno, Martina, Bartolucci, Gianluca, Osman, Sameh M., ALOthman, Zeid A., Cirilli, Roberto, Pierini, Marco, Monti, Simona Maria, Di Cesare Mannelli, Lorenzo, Gratteri, Paola, Ghelardini, Carla, De Simone, Giuseppina, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007106/
https://www.ncbi.nlm.nih.gov/pubmed/32364386
http://dx.doi.org/10.1021/acs.jmedchem.9b02135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007106/
https://www.ncbi.nlm.nih.gov/pubmed/32364386
http://dx.doi.org/10.1021/acs.jmedchem.9b02135

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