NOX4-Derived ROS Promotes Collagen I Deposition in Bronchial Smooth Muscle Cells by Activating Noncanonical p38MAPK/Akt-Mediated TGF-β Signaling

BACKGROUND: Airway smooth muscle (ASM) remodeling is a hallmark in chronic obstructive pulmonary disease (COPD). NADPH oxidase 4- (NOX4-) mediated reactive oxygen species (ROS) production plays a crucial role in cell differentiation and extracellular matrix (ECM) synthesis in ASM remodeling. However...

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Detalles Bibliográficos
Autores principales: Hao, Binwei, Sun, Ruiting, Guo, Xiaotong, Zhang, Lili, Cui, Jieda, Zhou, Yumin, Hong, Wei, Zhang, Yanan, He, Jinxi, Liu, Xiaoming, Li, Bing, Ran, Pixin, Chen, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007363/
https://www.ncbi.nlm.nih.gov/pubmed/33824697
http://dx.doi.org/10.1155/2021/6668971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007363/
https://www.ncbi.nlm.nih.gov/pubmed/33824697
http://dx.doi.org/10.1155/2021/6668971

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