Chronic treatment with the (iso-)glutaminyl cyclase inhibitor PQ529 is a novel and effective approach for glomerulonephritis in chronic kidney disease

Glomeruli and renal tubule injury in chronic kidney disease (CKD) is reported to involve induction of macrophage activation through the CCL2/CCR2 axis. The effects of inhibitors of the CCL2/CCR2 axis, such as anti-CCL2 antibody and CCR2 antagonist, on kidney function in animal models or humans with...

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Detalles Bibliográficos
Autores principales: Kanemitsu, Naotoshi, Kiyonaga, Fumiko, Mizukami, Kazuhiko, Maeno, Kyoichi, Nishikubo, Takashi, Yoshida, Hiroyuki, Ito, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007495/
https://www.ncbi.nlm.nih.gov/pubmed/33159802
http://dx.doi.org/10.1007/s00210-020-02013-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007495/
https://www.ncbi.nlm.nih.gov/pubmed/33159802
http://dx.doi.org/10.1007/s00210-020-02013-x

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