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Biochemical and structural characterization of analogs of MRE11 breast cancer-associated mutant F237C
The MRE11–RAD50–NBS1 (MRN) protein complex plays a vital role in DNA double strand break sensing, signaling, and repair. Mutation in any component of this complex may lead to disease as disrupting DNA double strand break repair has the potential to cause translocations and loss of genomic informatio...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007570/ https://www.ncbi.nlm.nih.gov/pubmed/33782469 http://dx.doi.org/10.1038/s41598-021-86552-0 |