Intracellular prostaglandin E2 contributes to hypoxia-induced proximal tubular cell death

Proximal tubular cells (PTC) are particularly vulnerable to hypoxia-induced apoptosis, a relevant factor for kidney disease. We hypothesized here that PTC death under hypoxia is mediated by cyclo-oxygenase (COX-2)-dependent production of prostaglandin E(2) (PGE(2)), which was confirmed in human prox...

Descripción completa

Detalles Bibliográficos
Autores principales: García-Pastor, Coral, Benito-Martínez, Selma, Bosch, Ricardo J., Fernández-Martínez, Ana B., Lucio-Cazaña, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007803/
https://www.ncbi.nlm.nih.gov/pubmed/33782420
http://dx.doi.org/10.1038/s41598-021-86219-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007803/
https://www.ncbi.nlm.nih.gov/pubmed/33782420
http://dx.doi.org/10.1038/s41598-021-86219-w

Ejemplares similares