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Intracellular prostaglandin E2 contributes to hypoxia-induced proximal tubular cell death

Proximal tubular cells (PTC) are particularly vulnerable to hypoxia-induced apoptosis, a relevant factor for kidney disease. We hypothesized here that PTC death under hypoxia is mediated by cyclo-oxygenase (COX-2)-dependent production of prostaglandin E(2) (PGE(2)), which was confirmed in human prox...

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Detalles Bibliográficos
Autores principales:	García-Pastor, Coral, Benito-Martínez, Selma, Bosch, Ricardo J., Fernández-Martínez, Ana B., Lucio-Cazaña, Francisco J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007803/ https://www.ncbi.nlm.nih.gov/pubmed/33782420 http://dx.doi.org/10.1038/s41598-021-86219-w

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