Developing a medium combination to attain similar glycosylation profile to originator by DoE and cluster analysis method

Glycosylation is critical for monoclonal antibody production because of its impact on pharmacokinetics and pharmacodynamics. Modulation of glycan profile is frequently needed in biosimilar development. However, glycosylation profile is not a single value like that of cell culture titer, hence making...

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Detalles Bibliográficos
Autores principales: Xu, Jian, Shao, Zhihui, Wang, Zhanqing, Huang, Yingfeng, Zou, Xun, Shen, Yaling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007809/
https://www.ncbi.nlm.nih.gov/pubmed/33782463
http://dx.doi.org/10.1038/s41598-021-86447-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007809/
https://www.ncbi.nlm.nih.gov/pubmed/33782463
http://dx.doi.org/10.1038/s41598-021-86447-0

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