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Developing a medium combination to attain similar glycosylation profile to originator by DoE and cluster analysis method
Glycosylation is critical for monoclonal antibody production because of its impact on pharmacokinetics and pharmacodynamics. Modulation of glycan profile is frequently needed in biosimilar development. However, glycosylation profile is not a single value like that of cell culture titer, hence making...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007809/ https://www.ncbi.nlm.nih.gov/pubmed/33782463 http://dx.doi.org/10.1038/s41598-021-86447-0 |