Absence of Pannexin 1 Stabilizes Hippocampal Excitability After Intracerebral Treatment With Aβ (1-42) and Prevents LTP Deficits in Middle-Aged Mice

Beta-amyloid protein [Aβ(1-42)] plays an important role in the disease progress and pathophysiology of Alzheimer's disease (AD). Membrane properties and neuronal excitability are altered in the hippocampus of transgenic AD mouse models that overexpress amyloid precursor protein. Although gap ju...

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Detalles Bibliográficos
Autores principales: Südkamp, Nicolina, Shchyglo, Olena, Manahan-Vaughan, Denise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007872/
https://www.ncbi.nlm.nih.gov/pubmed/33796018
http://dx.doi.org/10.3389/fnagi.2021.591735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007872/
https://www.ncbi.nlm.nih.gov/pubmed/33796018
http://dx.doi.org/10.3389/fnagi.2021.591735

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