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APOE4 Promotes Tonic-Clonic Seizures, an Effect Modified by Familial Alzheimer’s Disease Mutations

Seizures are emerging as a common symptom in Alzheimer’s disease (AD) patients, often attributed to high levels of amyloid β (Aβ). However, the extent that AD disease risk factors modulate seizure activity in aging and AD-relevant contexts is unclear. APOE4 is the greatest genetic risk factor for AD...

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Detalles Bibliográficos
Autores principales: Lamoureux, Lorissa, Marottoli, Felecia M., Tseng, Kuei Y., Tai, Leon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007905/
https://www.ncbi.nlm.nih.gov/pubmed/33796539
http://dx.doi.org/10.3389/fcell.2021.656521