Analysis of Gut Microbiome Using Explainable Machine Learning Predicts Risk of Diarrhea Associated With Tyrosine Kinase Inhibitor Neratinib: A Pilot Study

Neratinib has great efficacy in treating HER2+ breast cancer but is associated with significant gastrointestinal toxicity. The objective of this pilot study was to understand the association of gut microbiome and neratinib-induced diarrhea. Twenty-five patients (age ≥ 60) were enrolled in a phase II...

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Detalles Bibliográficos
Autores principales: Wong, Chi Wah, Yost, Susan E., Lee, Jin Sun, Gillece, John D., Folkerts, Megan, Reining, Lauren, Highlander, Sarah K., Eftekhari, Zahra, Mortimer, Joanne, Yuan, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008168/
https://www.ncbi.nlm.nih.gov/pubmed/33796451
http://dx.doi.org/10.3389/fonc.2021.604584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8008168/
https://www.ncbi.nlm.nih.gov/pubmed/33796451
http://dx.doi.org/10.3389/fonc.2021.604584

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